3JYI

Structural and biochemical evidence that a TEM-1 {beta}-lactamase Asn170Gly active site mutant acts via substrate-assisted catalysis

Summary for 3JYI

Entry DOI	10.2210/pdb3jyi/pdb
Related	1BTL 1FQG
Descriptor	Beta-lactamase TEM, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	beta-lactamase, enzyme, antibiotic resistance, disulfide bond, hydrolase, plasmid, transposable element
Biological source	Escherichia coli
Total number of polymer chains	6
Total formula weight	175119.37
Authors	Brown, N.G.,Palzkill, T.G.,Prasad, B.V.V.,Shanker, S. (deposition date: 2009-09-21, release date: 2009-10-06, Last modification date: 2023-09-06)
Primary citation	Brown, N.G.,Shanker, S.,Prasad, B.V.,Palzkill, T. Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis J.Biol.Chem., 284:33703-33712, 2009 Cited by PubMed: 19812041 DOI: 10.1074/jbc.M109.053819 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.703 Å)

Structure validation