3GGS
Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoro-2'-deoxyadenosine
Summary for 3GGS
| Entry DOI | 10.2210/pdb3ggs/pdb |
| Related | 3GB9 |
| Descriptor | Purine nucleoside phosphorylase, 5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | enzyme-prodrug complex, disease mutation, glycosyltransferase, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton : P00491 |
| Total number of polymer chains | 3 |
| Total formula weight | 107159.56 |
| Authors | Sawaya, M.R.,Afshar, S. (deposition date: 2009-03-02, release date: 2009-04-14, Last modification date: 2023-09-06) |
| Primary citation | Afshar, S.,Sawaya, M.R.,Morrison, S.L. Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. Protein Sci., 18:1107-1114, 2009 Cited by PubMed: 19388075DOI: 10.1002/pro.91 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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