3EM3

Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).

3EM3 の概要

• エントリーDOI: 10.2210/pdb3em3/pdb
• 関連するPDBエントリー: 3EKP 3EKQ 3EKT 3EKV 3EKW 3EKX 3EKY 3EL0 3EL1 3EL4 3EL5 3EM4 3EM6
• 分子名称: Protease, ACETATE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total)
• 機能のキーワード: protease inhibitor, hyper susceptibility, drug resistance, hiv, amprenavir, aids, hydrolase, protease
• 由来する生物種: HIV-1 M:B_ARV2/SF2 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22429.49

構造登録者

Prabu-Jeyabalan, M.,King, N.,Royer, C.,Schiffer, C. (登録日: 2008-09-23, 公開日: 2009-09-01, 最終更新日: 2023-09-06)

• 主引用文献: Prabu-Jeyabalan, M.,King, N.,Bandaranayake, R.,Nalivaika, E.,Schiffer, C.; Kinetic and Structural Studies on Atazanavir-specific I50L Drug-Resistant HIV-1 Protease Mutant; To be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)