3EBN

A Special Dimerization of SARS-CoV Main Protease C-Terminal Domain Due to Domain-swapping

Summary for 3EBN

• Entry DOI: 10.2210/pdb3ebn/pdb
• Descriptor: Replicase polyprotein 1ab (2 entities in total)
• Functional Keywords: sars, coronavirus, main protease, dimerization, n-finger, c-terminal domain, hydrolase
• Biological source: SARS coronavirus (SARS-CoV)
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P0C6X7
• Total number of polymer chains: 4
• Total formula weight: 52042.79

Authors

Zhong, N.,Zhang, S.,Xue, F.,Kang, X.,Lou, Z.,Xia, B. (deposition date: 2008-08-28, release date: 2009-05-19, Last modification date: 2023-11-01)

• Primary citation: Zhong, N.,Zhang, S.,Xue, F.,Kang, X.,Zou, P.,Chen, J.,Liang, C.,Rao, Z.,Jin, C.,Lou, Z.,Xia, B.; C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer; PROTEIN SCI., 18:839-844, 2009; PubMed: 19319935; DOI: 10.1002/pro.76

Experimental method

X-RAY DIFFRACTION (2.4 Å)