3DZI

Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex

3DZI の概要

• エントリーDOI: 10.2210/pdb3dzi/pdb
• 関連するPDBエントリー: 3DZF 3DZG 3DZH 3DZJ 3DZK
• 分子名称: ADP-ribosyl cyclase 1, 2-amino-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-9H-purin-6-yl 5-O-phosphono-beta-D-ribofuranoside, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: noncovalent intermediate, gtp complex, r5p-gtp adduct, beta sheets, alpha bundle, alternative splicing, diabetes mellitus, glycoprotein, hydrolase, membrane, nad, polymorphism, receptor, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens
• 細胞内の位置: Membrane; Single-pass type II membrane protein: P28907
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62233.35

構造登録者

Liu, Q.,Kriksunov, I.A.,Jiang, H.,Graeff, R.,Lin, H.,Lee, H.C.,Hao, Q. (登録日: 2008-07-29, 公開日: 2008-11-04, 最終更新日: 2023-08-30)

• 主引用文献: Liu, Q.,Kriksunov, I.A.,Jiang, H.,Graeff, R.,Lin, H.,Lee, H.C.,Hao, Q.; Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.; Chem.Biol., 15:1068-1078, 2008; PubMed: 18940667; DOI: 10.1016/j.chembiol.2008.08.007

実験手法

X-RAY DIFFRACTION (1.73 Å)