366D

1.3 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/6-BROMO-9-AMINO-DACA COMPLEX

Summary for 366D

• Entry DOI: 10.2210/pdb366d/pdb
• Descriptor: DNA (5'-D(*CP*GP*(BRU)P*AP*CP*G)-3'), 6-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total)
• Functional Keywords: dna, drug intercalation, major groove binding
• Total number of polymer chains: 1
• Total formula weight: 2652.67

Authors

Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Cardin, C.J. (deposition date: 1997-12-19, release date: 1999-04-06, Last modification date: 2024-02-21)

• Primary citation: Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.,Cardin, C.J.; Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.; J.Med.Chem., 42:536-540, 1999; PubMed: 10052960; DOI: 10.1021/jm980479u

Experimental method

X-RAY DIFFRACTION (1.3 Å)