316D

Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity

Summary for 316D

• Entry DOI: 10.2210/pdb316d/pdb
• Related: 173D 1A7Y 1A7Z 1DSC 1DSD 1FJA 1I3W 1L1V 1MNV 1OVF 1QFI 1UNJ 1UNM 209D 2D55
• Related PRD ID: PRD_000006
• Descriptor: DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), 8-FLUORO-ACTINOMYCIN D (2 entities in total)
• Functional Keywords: actinomycin d, actinomycin, f8-actinomycin, anti cancer, antitumor, chromophore, depsipeptide, dna-antibiotic complex, antibiotic, dna/antibiotic
• Biological source: STREPTOMYCES ANTIBIOTICUS
• Total number of polymer chains: 3
• Total formula weight: 6130.67

Authors

Takusagawa, F.,Takusagawa, K.T.,Carlson, R.G.,Weaver, R.F. (deposition date: 1997-03-05, release date: 1997-11-05, Last modification date: 2024-04-03)

• Primary citation: Takusagawa, F.,Takusagawa, K.T.,Carlson, R.G.,Weaver, R.F.; Selectivity of F8-Actinomycin D for RNA:DNA Hybrids and its Anti-Leukemia Activity.; Bioorg.Med.Chem., 5:1197-, 1997; PubMed: 9222513; DOI: 10.1016/S0968-0896(97)00062-X

Experimental method

X-RAY DIFFRACTION (3 Å)