303D

META-HYDROXY ANALOGUE OF HOECHST 33258 ('HYDROXYL OUT' CONFORMATION) BOUND TO D(CGCGAATTCGCG)2

Summary for 303D

• Entry DOI: 10.2210/pdb303d/pdb
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 3-[5-[5-(4-METHYL-PIPERAZIN-1-YL)-1H-IMIDAZO[4,5-B]PYRIDIN-2-YL]-BENZIMIDAZOL-2-YL]-PHENOL, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: b-dna, double helix, complexed with drug, dna
• Total number of polymer chains: 2
• Total formula weight: 7776.57

Authors

Clark, G.R.,Squire, C.J.,Gray, E.J.,Leupin, W.,Neidle, S. (deposition date: 1996-06-26, release date: 1997-01-20, Last modification date: 2024-04-03)

• Primary citation: Clark, G.R.,Squire, C.J.,Gray, E.J.,Leupin, W.,Neidle, S.; Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2.; Nucleic Acids Res., 24:4882-4889, 1996; PubMed: 9017011; DOI: 10.1093/nar/24.24.4882

Experimental method

X-RAY DIFFRACTION (2.2 Å)