2ZCH

Crystal structure of human prostate specific antigen complexed with an activating antibody

Summary for 2ZCH

• Entry DOI: 10.2210/pdb2zch/pdb
• Related: 2ZCK 2ZCL
• Descriptor: Prostate-specific antigen, monoclonal antibody 8G8F5 Fab, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: human psa, kallikrein related peptidases, antibodies, prostate cancer, glycoprotein, hydrolase, polymorphism, protease, secreted, serine protease, zymogen, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P07288
• Total number of polymer chains: 3
• Total formula weight: 74505.80

Authors

Menez, R.,Stura, E.,Jolivet-Reynaud, C. (deposition date: 2007-11-08, release date: 2008-01-29, Last modification date: 2023-11-01)

• Primary citation: Michel, S.,Muller, B.H.,Bossus, M.,Ducancel, F.,Jolivet-Reynaud, C.,Stura, E.A.; Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody; J.Mol.Biol., 376:1021-1033, 2008; PubMed: 18187150; DOI: 10.1016/j.jmb.2007.11.052

Experimental method

X-RAY DIFFRACTION (2.83 Å)