Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2YM4

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2YM4
Entry DOI10.2210/pdb2ym4/pdb
Related1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YER 2YEX 2YM3 2YM5 2YM6 2YM7 2YM8
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK1, ethyl 4-[(2R)-2-(aminomethyl)morpholin-4-yl]-3-(3-cyanophenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstransferase, dna repair, serine/threonine kinase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: O14757
Total number of polymer chains1
Total formula weight33635.63
Authors
Primary citationReader, J.C.,Matthews, T.P.,Klair, S.,Cheung, K.M.J.,Scanlon, J.,Proisy, N.,Addison, G.,Ellard, J.,Piton, N.,Taylor, S.,Cherry, M.,Fisher, M.,Boxall, K.,Burns, S.,Walton, M.I.,Westwood, I.M.,Hayes, A.,Eve, P.,Valenti, M.,De Haven Brandon, A.,Box, G.,Van Montfort, R.L.M.,Williams, D.H.,Aherne, G.W.,Raynaud, F.I.,Eccles, S.A.,Garrett, M.D.,Collins, I.
Structure-Guided Evolution of Potent and Selective Chk1 Inhibitors Through Scaffold Morphing.
J.Med.Chem., 54:8328-, 2011
Cited by
PubMed: 22111927
DOI: 10.1021/JM2007326
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon