2YH1

Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding

Summary for 2YH1

• Entry DOI: 10.2210/pdb2yh1/pdb
• Related: 1JMT 1O0P 1OPI 1U2F 2G4B 2U2F 2YH0 2YH4
• NMR Information: BMRB: 17623
• Descriptor: SPLICING FACTOR U2AF 65 KDA SUBUNIT, 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3' (2 entities in total)
• Functional Keywords: transcription, pre-mrna splicing
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 24221.06

Authors

Mackereth, C.D.,Madl, T.,Simon, B.,Zanier, K.,Gasch, A.,Sattler, M. (deposition date: 2011-04-26, release date: 2011-07-20, Last modification date: 2019-09-25)

• Primary citation: Mackereth, C.D.,Madl, T.,Bonnal, S.,Simon, B.,Zanier, K.,Gasch, A.,Rybin, V.,Valcarcel, J.,Sattler, M.; Multi-Domain Conformational Selection Underlies Pre-Mrna Splicing Regulation by U2Af; Nature, 475:408-, 2011; PubMed: 21753750; DOI: 10.1038/NATURE10171

Experimental method

SOLUTION NMR