2YAK

Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV)

Summary for 2YAK

Entry DOI	10.2210/pdb2yak/pdb
Related	1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V
Descriptor	DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4 (3 entities in total)
Functional Keywords	transferase, octahedral ruthenium inhibitory complex, kinase inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P53355
Total number of polymer chains	1
Total formula weight	33433.15
Authors	Feng, L.,Geisselbrecht, Y.,Blanck, S.,Wilbuer, A.,Atilla-Gokcumen, G.E.,Filippakopoulos, P.,Kraeling, K.,Celik, M.A.,Harms, K.,Maksimoska, J.,Marmorstein, R.,Frenking, G.,Knapp, S.,Essen, L.-O.,Meggers, E. (deposition date: 2011-02-23, release date: 2011-04-27, Last modification date: 2011-07-13)
Primary citation	Feng, L.,Geisselbrecht, Y.,Blanck, S.,Wilbuer, A.,Atilla-Gokcumen, G.E.,Filippakopoulos, P.,Kraeling, K.,Celik, M.A.,Harms, K.,Maksimoska, J.,Marmorstein, R.,Frenking, G.,Knapp, S.,Essen, L.O.,Meggers, E. Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors. J.Am.Chem.Soc., 133:5976-, 2011 Cited by PubMed: 21446733 DOI: 10.1021/JA1112996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation