2YAD

BRICHOS domain of Surfactant protein C precursor protein

Summary for 2YAD

• Entry DOI: 10.2210/pdb2yad/pdb
• Descriptor: SURFACTANT PROTEIN C BRICHOS DOMAIN (2 entities in total)
• Functional Keywords: pulmonary surfactant system, interstitial lung disease, amyloid, chaperone, surfactant protein
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 6
• Total formula weight: 112253.30

Authors

Askarieh, G.,Siponen, M.I.,Willander, H.,Landreh, M.,Westermark, P.,Nordling, K.,Keranen, H.,Hermansson, E.,Hamvas, A.,Nogee, L.M.,Bergman, T.,Saenz, A.,Casals, C.,Aqvist, J.,Jornvall, H.,Presto, J.,Johansson, J.,Arrowsmith, C.H.,Bountra, C.,Collins, R.,Edwards, A.M.,Ekblad, T.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kol, S.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nyman, T.,Nordlund, P.,Persson, C.,Schuler, H.,Thorsell, A.G.,Tresaugues, L.,van den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Berglund, H.,Knight, S.D. (deposition date: 2011-02-18, release date: 2012-02-15, Last modification date: 2014-08-13)

• Primary citation: Willander, H.,Askarieh, G.,Landreh, M.,Westermark, P.,Nordling, K.,Keranen, H.,Hermansson, E.,Hamvas, A.,Nogee, L.M.,Bergman, T.,Saenz, A.,Casals, C.,Aqvist, J.,Jornvall, H.,Berglund, H.,Presto, J.,Knight, S.D.,Johansson, J.; High Resolution Structure of a Bricos Domain and its Implications for Anti-Amyloid Chaperone Activity on Lung Surgactant Protein C.; Proc.Natl.Acad.Sci.USA, 109:2325-, 2012; PubMed: 22308375; DOI: 10.1073/PNAS.1114740109

Experimental method

X-RAY DIFFRACTION (2.2 Å)