2XYQ

Crystal structure of the nsp16 nsp10 SARS coronavirus complex

Summary for 2XYQ

• Entry DOI: 10.2210/pdb2xyq/pdb
• Related: 1O5S 1P76 1P9T 1PA5 1PUK 1Q1X 1SXF 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1YSY 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2V6N 2XYR 2XYV
• Descriptor: PUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, CHLORIDE ION, ... (8 entities in total)
• Functional Keywords: transferase-viral protein complex, rossmann fold, transferase/viral protein
• Biological source: SARS CORONAVIRUS; More
• Cellular location: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7 P0C6X7
• Total number of polymer chains: 2
• Total formula weight: 46400.89

Authors

Decroly, E.,Debarnot, C.,Ferron, F.,Bouvet, M.,Coutard, B.,Imbert, I.,Gluais, L.,Papageorgiou, N.,Ortiz-Lombardia, M.,Lescar, J.,Canard, B. (deposition date: 2010-11-18, release date: 2011-10-19, Last modification date: 2023-12-20)

• Primary citation: Decroly, E.,Debarnot, C.,Ferron, F.,Bouvet, M.,Coutard, B.,Imbert, I.,Gluais, L.,Papageorgiou, N.,Sharff, A.,Bricogne, G.,Ortiz-Lombardia, M.,Lescar, J.,Canard, B.; Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.; Plos Pathog., 7:2059-, 2011; PubMed: 21637813; DOI: 10.1371/JOURNAL.PPAT.1002059

Experimental method

X-RAY DIFFRACTION (2 Å)