2XWJ

Crystal Structure of Complement C3b in Complex with Factor B

Summary for 2XWJ

• Entry DOI: 10.2210/pdb2xwj/pdb
• Related: 1C3D 1DLE 1GHQ 1Q0P 1RRK 1RS0 1RTK 1W2S 2A73 2A74 2HR0 2WII 2WIN 2WY7 2WY8 2XQW 2XW9 2XWA 2XWB
• Descriptor: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT FACTOR B, ... (6 entities in total)
• Functional Keywords: immune system, pro-convertase, hydrolase, serine protease, conformational changes, alternative pathway
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01024 P01024 P00751
• Total number of polymer chains: 12
• Total formula weight: 1036653.74

Authors

Forneris, F.,Ricklin, D.,Wu, J.,Tzekou, A.,Wallace, R.S.,Lambris, J.D.,Gros, P. (deposition date: 2010-11-04, release date: 2011-01-12, Last modification date: 2023-12-20)

• Primary citation: Forneris, F.,Ricklin, D.,Wu, J.,Tzekou, A.,Wallace, R.S.,Lambris, J.D.,Gros, P.; Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.; Science, 330:1816-, 2010; PubMed: 21205667; DOI: 10.1126/SCIENCE.1195821

Experimental method

X-RAY DIFFRACTION (4 Å)