2XRW

Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4

Summary for 2XRW

• Entry DOI: 10.2210/pdb2xrw/pdb
• Related: 2XS0
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 8, NUCLEAR FACTOR OF ACTIVATED T-CELLS\, CYTOPLASMIC 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: transcription, mapk signaling pathways, linear binding motif
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: Q12968
• Total number of polymer chains: 2
• Total formula weight: 45205.72

Authors

Barkai, T.,Toeoroe, I.,Garai, A.,Remenyi, A. (deposition date: 2010-09-23, release date: 2011-09-28, Last modification date: 2023-12-20)

• Primary citation: Garai, A.,Zeke, A.,Gogl, G.,Toro, I.,Fordos, F.,Blankenburg, H.,Barkai, T.,Varga, J.,Alexa, A.,Emig, D.,Albrecht, M.,Remenyi, A.; Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.; Sci. Signal, 5:74-, 2012; PubMed: 23047924; DOI: 10.1126/SCISIGNAL.2003004

Experimental method

X-RAY DIFFRACTION (1.33 Å)