2XF0

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2XF0

Entry DOI	10.2210/pdb2xf0/pdb
Related	1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK1, 3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transferase, dna repair, cell cycle
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	33552.54
Authors	Matthews, T.P.,McHardy, T.,Klair, S.,Boxall, K.,Fisher, M.,Cherry, M.,Allen, C.E.,Addison, G.J.,Ellard, J.,Aherne, G.W.,Westwood, I.M.,van Montfort, R.,Garrett, M.D.,Reader, J.C.,Collins, I. (deposition date: 2010-05-19, release date: 2010-06-30, Last modification date: 2023-12-20)
Primary citation	Matthews, T.P.,Mchardy, T.,Klair, S.,Boxall, K.,Fisher, M.,Cherry, M.,Allen, C.E.,Addison, G.J.,Ellard, J.,Aherne, G.W.,Westwood, I.M.,Montfort, R.V.,Garrett, M.D.,Reader, J.C.,Collins, I. Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases. Bioorg.Med.Chem.Lett., 20:4045-, 2010 Cited by PubMed: 20561787 DOI: 10.1016/J.BMCL.2010.05.096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation