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2X8B

Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II

Summary for 2X8B
Entry DOI10.2210/pdb2x8b/pdb
Related1B41 1F8U 1FSC 1FSS 1KU6 1MAH 1PUV 1PUW 1VZJ 2CLJ
DescriptorACETHYLCHOLINESTERASE, FASCICULIN-2, CHLORIDE ION, ... (7 entities in total)
Functional Keywordshydrolase-toxin complex, cell junction, hydrolase, gpi-anchor, neurotransmitter degradation, tabun, aging, serine esterase, blood group antigen, hydrolase/toxin
Biological sourceHOMO SAPIENS (HUMAN)
More
Total number of polymer chains2
Total formula weight72446.02
Authors
Carletti, E.,Colletier, J.P.,Nachon, F. (deposition date: 2010-03-08, release date: 2010-04-28, Last modification date: 2023-12-20)
Primary citationCarletti, E.,Colletier, J.P.,Dupeux, F.,Trovaslet, M.,Masson, P.,Nachon, F.
Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.
J. Med. Chem., 53:4002-4008, 2010
Cited by
PubMed: 20408548
DOI: 10.1021/jm901853b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.95 Å)
Structure validation

217705

數據於2024-03-27公開中

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