2X1N

Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design

Replaces:  2WHA

Summary for 2X1N

Related1H08 1PYE 2VTH 2B53 1V1K 1KE7 1OKV 1H25 1PXK 2WIH 2BHH 2VTA 2UUE 1GZ8 1E1V 1OL2 1H27 1JSV 2WHA 2B52 1KE5 1FIN 2C5O 2C68 2VTT 1P2A 2VTQ 2C4G 1H1Q 1W0X 2W05 1PXO 1KE9 2A0C 1HCK 1JSU 1PXN 2UZE 2V0D 2VTM 1OIQ 1H1R 2IW8 1HCL 1PW2 1GIH 2WHB 2VTN 2W06 1JST 1OIU 1B38 1PXM 1FQ1 1VYW 1H1P 2WMA 2C69 1URC 1PXI 2C6I 2WXV 1YKR 2W17 2UZD 2C6K 2C5Y 1WCC 2J9M 1VYZ 2VTI 1JVP 1W98 2WIP 1PKD 1P5E 2VTS 2C5P 2UZN 2B54 1KE6 1PXJ 2UZL 2CCI 2BKZ 2G9X 1Y91 2IW6 1GIJ 1R78 1H0V 2IW9 1W8C 1BUH 2BPM 2BTS 1FVV 1OKW 2VTP 2A4L 2C6T 1FVT 1QMZ 2W1H 2VU3 2B55 1OGU 1PF8 1H1S 2C5V 2JGZ 2BHE 1URW 1OIY 2C6L 1F5Q 2C6O 2VTL 1OL1 1H01 2WFY 2UZB 1OIR 1OI9 2VTJ 2CJM 2C5X 2WEV 2C5N 2C6M 1OIT 2V22 1GY3 1DI8 1GII 2VV9 2WPA 1E9H 2WMB 2VTO 1DM2 1H24 2UZO 2EXM 1H00 2CLX 1PXP 2CCH 1B39 2BTR 1AQ1 1H0W 1G5S 1CKP 1KE8 1H28 1PXL 2VTR 1H26 1E1X 1H07 1Y8Y
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, ACE-LEU-ASN-PFF-NH2, ... (5 entities in total)
Functional Keywordsinhibition, transferase, serine/threonine-protein kinase, cell cycle, cell division
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Nucleus  P20248
Total number of polymer chains5
Total molecular weight128999.49
Authors
Primary citation
Mcintyre, N.A.,Mcinnes, C.,Griffiths, G.,Barnett, A.L.,Kontopidis, G.,Slawin, A.M.Z.,Jackson, W.,Thomas, M.,Zheleva, D.I.,Wang, S.,Blake, D.G.,Westwood, N.J.,Fischer, P.M.
Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-Aryl-4,5-Dihydrothiazolo[4,5-H]Quinazolin-8-Amines as Ring-Constrained 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Cyclin-Dependent Kinase Inhibitors.
J.Med.Chem., 53:2136-, 2010
PubMed: 20146435 (PDB entries with the same primary citation)
DOI: 10.1021/JM901660C
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25481.4%5.5%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report