2WUZ

X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation

Summary for 2WUZ

• Entry DOI: 10.2210/pdb2wuz/pdb
• Related: 2WV2 2WX2
• Descriptor: LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
• Functional Keywords: oxidoreductase, methyltransferase, p450, iron, cyp51, metal-binding, ergosterol biosynthesis
• Biological source: TRYPANOSOMA CRUZI
• Total number of polymer chains: 2
• Total formula weight: 110087.05

Authors

Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2009-10-11, release date: 2009-10-20, Last modification date: 2023-12-20)

• Primary citation: Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M.; Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole; Plos Negl Trop Dis, 4:E651-, 2010; PubMed: 20386598; DOI: 10.1371/JOURNAL.PNTD.0000651

Experimental method

X-RAY DIFFRACTION (2.35 Å)