2WTV

Aurora-A Inhibitor Structure

Summary for 2WTV

Entry DOI	10.2210/pdb2wtv/pdb
Related	1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTW
Descriptor	SERINE/THREONINE-PROTEIN KINASE 6 AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-A, AURORA-RELATED KINASE 1, HARK1, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	kinase, cell cycle, transferase, phosphoprotein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	4
Total formula weight	136193.44
Authors	Kosmopoulou, M.,Bayliss, R. (deposition date: 2009-09-22, release date: 2010-01-26, Last modification date: 2023-12-20)
Primary citation	Dodson, C.A.,Kosmopoulou, M.,Richards, M.W.,Atrash, B.,Bavetsias, V.,Blagg, J.,Bayliss, R. Crystal Structure of an Aurora-A Mutant that Mimics Aurora-B Bound to Mln8054: Insights Into Selectivity and Drug Design. Biochem.J., 427:19-, 2010 Cited by PubMed: 20067443 DOI: 10.1042/BJ20091530 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation