2WHW

Selective oxidation of carbolide C-H bonds by engineered macrolide P450 monooxygenase

Summary for 2WHW

Entry DOI	10.2210/pdb2whw/pdb
Related	2BVJ 2C6H 2C7X 2CA0 2CD8 2VZ7 2VZM 2WI9
Descriptor	CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CYCLOTRIDECYL 3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSIDE, ... (5 entities in total)
Functional Keywords	antibiotic biosynthesis, cyp107l1, cytochrome p450, heme, iron, macrolide monooxygenase, metal-binding, monooxygenase, oxidoreductase, oxidoreductase antibiotic biosynthesis, pikc
Biological source	STREPTOMYCES VENEZUELAE
Total number of polymer chains	2
Total formula weight	98499.49
Authors	Li, S.,Chaulagain, M.R.,Knauff, A.R.,Podust, L.M.,Montgomery, J.,Sherman, D.H. (deposition date: 2009-05-07, release date: 2009-10-27, Last modification date: 2023-12-13)
Primary citation	Li, S.,Chaulagain, M.R.,Knauff, A.R.,Podust, L.M.,Montgomery, J.,Sherman, D.H. Selective Oxidation of Carbolide C-H Bonds by an Engineered Macrolide P450 Mono-Oxygenase. Proc.Natl.Acad.Sci.USA, 106:18463-, 2009 Cited by PubMed: 19833867 DOI: 10.1073/PNAS.0907203106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation