2WED

ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE MACROCYCLIC INHIBITOR:METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT

Replaces:  1WED

Summary for 2WED

• Entry DOI: 10.2210/pdb2wed/pdb
• Descriptor: PENICILLOPEPSIN, alpha-D-mannopyranose, SULFATE ION, ... (5 entities in total)
• Functional Keywords: penicillopepsin, macrocyclic inhibitor, hydrolase
• Biological source: Penicillium janthinellum
• Cellular location: Secreted : P00798
• Total number of polymer chains: 1
• Total formula weight: 34476.73

Authors

Ding, J.,Fraser, M.E.,James, M.N.G. (deposition date: 1998-02-03, release date: 1998-05-27, Last modification date: 2020-07-29)

• Primary citation: Ding, J.,Fraser, M.E.,Meyer, J.H.,Bartlett, P.A.,James, M.N.G.; Macrocyclic Inhibitors of Penicillopepsin. II. X-Ray Crystallographic Analyses of Penicillopepsin Complexed with a P3-P1 Macrocyclic Peptidyl Inhibitor and with its Two Acyclic Analogues; J.Am.Chem.Soc., 120:4610-4621, 1998

Experimental method

X-RAY DIFFRACTION (1.5 Å)