2VWV
ephB4 kinase domain inhibitor complex
Summary for 2VWV
| Entry DOI | 10.2210/pdb2vwv/pdb |
| Related | 2BBA 2VWU 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 |
| Descriptor | EPHRIN TYPE-B RECEPTOR 4, N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE (3 entities in total) |
| Functional Keywords | tyrosine-protein kinase, receptor tyrosine kinase, kinase, mutant, membrane, receptor, transferase, atp-binding, polymorphism, glycoprotein, transmembrane, phosphoprotein, unphosphorylated, nucleotide-binding |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 1 |
| Total formula weight | 34352.66 |
| Authors | Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L.,Kettle, J.G.,Leach, A.G. (deposition date: 2008-06-27, release date: 2008-07-08, Last modification date: 2023-12-13) |
| Primary citation | Bardelle, C.,Cross, D.,Davenport, S.,Kettle, J.G.,Ko, E.J.,Leach, A.G.,Mortlock, A.,Read, J.,Roberts, N.J.,Robins, P.,Williams, E.J. Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines Bioorg.Med.Chem.Lett., 18:2776-, 2008 Cited by PubMed: 18434142DOI: 10.1016/J.BMCL.2008.04.015 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
