2UV3

Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.

Summary for 2UV3

Entry DOI	10.2210/pdb2uv3/pdb
Descriptor	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywords	cd47-binding domain of sirp-alpha, receptor, membrane, sh3- binding, glycoprotein, transmembrane, phosphorylation, human sirp-alpha n terminal v domain, immunoglobulin domain, signal-regulatory protein alpha
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	28805.98
Authors	Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N. (deposition date: 2007-03-08, release date: 2007-03-27, Last modification date: 2011-07-13)
Primary citation	Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N. The Structure of the Macrophage Signal Regulatory Protein Alpha (Sirpalpha) Inhibitory Receptor Reveals a Binding Face Reminiscent of that Used by T Cell Receptors. J.Biol.Chem., 282:14567-, 2007 Cited by PubMed: 17369261 DOI: 10.1074/JBC.M611511200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation