2RJQ
Crystal structure of ADAMTS5 with inhibitor bound
Summary for 2RJQ
Entry DOI | 10.2210/pdb2rjq/pdb |
Related | 2RJP 3B2Z |
Descriptor | ADAMTS-5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total) |
Functional Keywords | metalloprotease domain, aggrecanase, cleavage on pair of basic residues, extracellular matrix, glycoprotein, hydrolase, metal-binding, secreted, zymogen |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42835.16 |
Authors | Mosyak, L.,Stahl, M.,Somers, W. (deposition date: 2007-10-15, release date: 2007-12-11, Last modification date: 2023-08-30) |
Primary citation | Mosyak, L.,Georgiadis, K.,Shane, T.,Svenson, K.,Hebert, T.,McDonagh, T.,Mackie, S.,Olland, S.,Lin, L.,Zhong, X.,Kriz, R.,Reifenberg, E.L.,Collins-Racie, L.A.,Corcoran, C.,Freeman, B.,Zollner, R.,Marvell, T.,Vera, M.,Sum, P.E.,Lavallie, E.R.,Stahl, M.,Somers, W. Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17:16-21, 2008 Cited by PubMed: 18042673DOI: 10.1110/ps.073287008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report