2RFI

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide

Summary for 2RFI

• Entry DOI: 10.2210/pdb2rfi/pdb
• Related: 2IGQ
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Histone H3, ZINC ION, ... (5 entities in total)
• Functional Keywords: euchromatic histone methyltransferase 1, structural genomics, structural genomics consortium, sgc, alternative splicing, ank repeat, chromatin regulator, nucleus, phosphorylation, polymorphism, s-adenosyl-l-methionine, acetylation, chromosomal protein, dna damage, dna repair, dna-binding, methylation, nucleosome core, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9H9B1
• Total number of polymer chains: 4
• Total formula weight: 69281.16

Authors

Min, J.,Wu, H.,Loppnau, P.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Plotnikov, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2007-09-30, release date: 2007-10-23, Last modification date: 2023-08-30)

• Primary citation: Wu, H.,Min, J.,Lunin, V.V.,Antoshenko, T.,Dombrovski, L.,Zeng, H.,Allali-Hassani, A.,Campagna-Slater, V.,Vedadi, M.,Arrowsmith, C.H.,Plotnikov, A.N.,Schapira, M.; Structural biology of human H3K9 methyltransferases; Plos One, 5:e8570-e8570, 2010; PubMed: 20084102; DOI: 10.1371/journal.pone.0008570

Experimental method

X-RAY DIFFRACTION (1.59 Å)