Crystal structure of the human beta2 adrenoceptor

Summary for 2R4R

DescriptorBeta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, antibody for beta2 adrenoceptor, heavy chain (3 entities in total)
Functional Keywordstransmembrane helix, g-protein coupled receptor, glycoprotein, lipoprotein, palmitate, phosphorylation, receptor, transducer, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein P07550
Total number of polymer chains3
Total molecular weight88420.37
Primary citation
Rasmussen, S.G.F.,Choi, H.J.,Rosenbaum, D.M.,Kobilka, T.S.,Thian, F.S.,Edwards, P.C.,Burghammer, M.,Ratnala, V.R.,Sanishvili, R.,Fischetti, R.F.,Schertler, G.F.,Weis, W.I.,Kobilka, B.K.
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450:383-387, 2007
PubMed: 17952055 (PDB entries with the same primary citation)
DOI: 10.1038/nature06325
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.271575.9%11.3%10.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2r4r
no rotation
Molmil generated image of 2r4r
rotated about x axis by 90°
Molmil generated image of 2r4r
rotated about y axis by 90°