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2R42

The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Summary for 2R42
Entry DOI10.2210/pdb2r42/pdb
Related2R3V
DescriptorMevalonate kinase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ... (4 entities in total)
Functional Keywordsmevalonate kinase, farnesyl thiodiphosphate, atp-binding, cholesterol biosynthesis, cytoplasm, lipid synthesis, nucleotide-binding, peroxisome, steroid biosynthesis, sterol biosynthesis, transferase
Biological sourceRattus norvegicus (Rat)
Cellular locationCytoplasm: P17256
Total number of polymer chains1
Total formula weight42455.33
Authors
Fu, Z.,Voynova, N.E.,Miziorko, H.M.,Kim, J.P. (deposition date: 2007-08-30, release date: 2008-06-24, Last modification date: 2024-02-21)
Primary citationFu, Z.,Voynova, N.E.,Herdendorf, T.J.,Miziorko, H.M.,Kim, J.J.
Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism.
Biochemistry, 47:3715-3724, 2008
Cited by
PubMed: 18302342
DOI: 10.1021/bi7024386
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

数据于2024-03-27公开中

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