2R42
The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Summary for 2R42
Entry DOI | 10.2210/pdb2r42/pdb |
Related | 2R3V |
Descriptor | Mevalonate kinase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | mevalonate kinase, farnesyl thiodiphosphate, atp-binding, cholesterol biosynthesis, cytoplasm, lipid synthesis, nucleotide-binding, peroxisome, steroid biosynthesis, sterol biosynthesis, transferase |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Cytoplasm: P17256 |
Total number of polymer chains | 1 |
Total formula weight | 42455.33 |
Authors | Fu, Z.,Voynova, N.E.,Miziorko, H.M.,Kim, J.P. (deposition date: 2007-08-30, release date: 2008-06-24, Last modification date: 2024-02-21) |
Primary citation | Fu, Z.,Voynova, N.E.,Herdendorf, T.J.,Miziorko, H.M.,Kim, J.J. Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism. Biochemistry, 47:3715-3724, 2008 Cited by PubMed: 18302342DOI: 10.1021/bi7024386 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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