2R0K

Protease domain of HGFA with inhibitor Fab58

Summary for 2R0K

• Entry DOI: 10.2210/pdb2r0k/pdb
• Related: 1YBW 1YC0 2R0L
• Descriptor: Hepatocyte growth factor activator, antibody light chain of Fab58, antibody heavy chain of Fab58, Fab portion only (3 entities in total)
• Functional Keywords: serine protease, antibody, inhibitor, egf-like domain, glycoprotein, hydrolase, kringle, secreted, zymogen, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q04756
• Total number of polymer chains: 3
• Total formula weight: 77861.43

Authors

Eigenbrot, C.,Shia, S. (deposition date: 2007-08-20, release date: 2007-12-25, Last modification date: 2023-08-30)

• Primary citation: Wu, Y.,Eigenbrot, C.,Liang, W.C.,Stawicki, S.,Shia, S.,Fan, B.,Ganesan, R.,Lipari, M.T.,Kirchhofer, D.; Structural insight into distinct mechanisms of protease inhibition by antibodies.; Proc.Natl.Acad.Sci.Usa, 104:19784-19789, 2007; PubMed: 18077410; DOI: 10.1073/pnas.0708251104

Experimental method

X-RAY DIFFRACTION (3.51 Å)