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2QFO

HSP90 complexed with A143571 and A516383

Summary for 2QFO
Entry DOI10.2210/pdb2qfo/pdb
DescriptorHeat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains2
Total formula weight46634.78
Authors
Park, C.H. (deposition date: 2007-06-27, release date: 2008-07-01, Last modification date: 2023-08-30)
Primary citationHuth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
CHEM.BIOL.DRUG DES., 70:1-12, 2007
Cited by
PubMed: 17630989
DOI: 10.1111/j.1747-0285.2007.00535.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.68 Å)
Structure validation

217705

数据于2024-03-27公开中

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