2QF6

HSP90 complexed with A56322

Summary for 2QF6

• Entry DOI: 10.2210/pdb2qf6/pdb
• Descriptor: Heat shock protein HSP 90-alpha, 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE (3 entities in total)
• Functional Keywords: protein-inhibitor complex, chaperone
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 4
• Total formula weight: 93857.62

Authors

Park, C.H. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2023-08-30)

• Primary citation: Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.; Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.; Chem.Biol.Drug Des., 70:1-12, 2007; PubMed: 17630989; DOI: 10.1111/j.1747-0285.2007.00535.x

Experimental method

X-RAY DIFFRACTION (3.1 Å)