2QE2

Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

Summary for 2QE2

• Entry DOI: 10.2210/pdb2qe2/pdb
• Related: 2QE5
• Descriptor: RNA-directed RNA polymerase, 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID (2 entities in total)
• Functional Keywords: transferase
• Biological source: Hepatitis C virus subtype 1b
• Total number of polymer chains: 2
• Total formula weight: 129224.71

Authors

Chopra, R.,Svenson, K.,Bard, J. (deposition date: 2007-06-22, release date: 2007-10-02, Last modification date: 2023-08-30)

• Primary citation: Nittoli, T.,Curran, K.,Insaf, S.,DiGrandi, M.,Orlowski, M.,Chopra, R.,Agarwal, A.,Howe, A.Y.M.,Prashad, A.,Brawner Floyd, M.,Johnson, B.,Sutherland, A.,Wheless, K.,Feld, B.,O'Connell, J.,Mansour, T.S.,Bloom, J.; Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase; J.Med.Chem., 50:2108-2116, 2007; PubMed: 17402724; DOI: 10.1021/jm061428x

Experimental method

X-RAY DIFFRACTION (2.9 Å)