2PZY

Structure of MK2 Complexed with Compound 76

Summary for 2PZY

• Entry DOI: 10.2210/pdb2pzy/pdb
• Descriptor: MAP kinase-activated protein kinase 2, (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, STAUROSPORINE (3 entities in total)
• Functional Keywords: mk2, protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 151432.90

Authors

White, A.,Wu, J.P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B. (deposition date: 2007-05-18, release date: 2007-07-31, Last modification date: 2024-02-21)

• Primary citation: Wu, J.-P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B.,White, A.; The discovery of carboline analogs as potent MAPKAP-K2 inhibitors; Bioorg.Med.Chem.Lett., 17:4664-4669, 2007; PubMed: 17576063; DOI: 10.1016/j.bmcl.2007.05.101

Experimental method

X-RAY DIFFRACTION (2.9 Å)