2PWX

Crystal structure of G11A mutant of SARS-CoV 3C-like protease

Summary for 2PWX

• Entry DOI: 10.2210/pdb2pwx/pdb
• Descriptor: 3C-like proteinase (2 entities in total)
• Functional Keywords: chymotrypsin fold, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 1
• Total formula weight: 34034.79

Authors

Chen, S.,Hu, T.,Jiang, H.,Shen, X. (deposition date: 2007-05-14, release date: 2007-10-30, Last modification date: 2024-02-21)

• Primary citation: Chen, S.,Hu, T.,Zhang, J.,Chen, J.,Chen, K.,Ding, J.,Jiang, H.,Shen, X.; Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.; J.Biol.Chem., 283:554-564, 2008; PubMed: 17977841; DOI: 10.1074/jbc.M705240200

Experimental method

X-RAY DIFFRACTION (2.5 Å)