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2PVY

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.

Summary for 2PVY
Entry DOI10.2210/pdb2pvy/pdb
Related2PSQ 2PVF 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B
DescriptorFibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
Functional Keywordskinase domain fold consisting of n- and c-lobes, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains4
Total formula weight150787.10
Authors
Chen, H.,Mohammadi, M. (deposition date: 2007-05-10, release date: 2007-09-25, Last modification date: 2023-08-30)
Primary citationChen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M.
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27:717-730, 2007
Cited by
PubMed: 17803937
DOI: 10.1016/j.molcel.2007.06.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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