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2PGQ

Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK

Summary for 2PGQ
Entry DOI10.2210/pdb2pgq/pdb
Related1SHH 2PGB
Related PRD IDPRD_000020
DescriptorThrombin light chain, Thrombin heavy chain, ZINC ION, ... (6 entities in total)
Functional Keywordsserine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight35868.32
Authors
Bush-Pelc, L.A.,Marino, F.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E. (deposition date: 2007-04-10, release date: 2007-07-17, Last modification date: 2024-03-13)
Primary citationBush-Pelc, L.A.,Marino, F.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.
Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282:27165-27170, 2007
Cited by
PubMed: 17636263
DOI: 10.1074/jbc.M703202200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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