2P4Y

Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator

Summary for 2P4Y

• Entry DOI: 10.2210/pdb2p4y/pdb
• Related: 1ZEO
• Descriptor: Peroxisome proliferator-activated receptor gamma, (2R)-2-(4-CHLORO-3-{[3-(6-METHOXY-1,2-BENZISOXAZOL-3-YL)-2-METHYL-6-(TRIFLUOROMETHOXY)-1H-INDOL-1-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: nuclear receptor, ligand binding domain, lbd, alpha helix sandwich, ppar-homodimer, sppargm, partial agonist, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 64459.30

Authors

McKeever, B.M. (deposition date: 2007-03-13, release date: 2008-01-08, Last modification date: 2024-04-03)

• Primary citation: Einstein, M.,Akiyama, T.E.,Castriota, G.A.,Wang, C.F.,McKeever, B.,Mosley, R.T.,Becker, J.W.,Moller, D.E.,Meinke, P.T.,Wood, H.B.,Berger, J.P.; The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.; Mol.Pharmacol., 73:62-74, 2008; PubMed: 17940191; DOI: 10.1124/mol.107.041202

Experimental method

X-RAY DIFFRACTION (2.25 Å)