2P41

Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine

Summary for 2P41

Entry DOI	10.2210/pdb2p41/pdb
Related	1L9K 2P1D 2P3L 2P3O 2P3Q 2P40
Descriptor	type II methyltransferase, SULFATE ION, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE, ... (7 entities in total)
Functional Keywords	vizier; viral enzymes involved in replication; dengue virus methyltransferase; structural genomics; marseilles structural genomics program @ afmb; msgp, viral protein, transferase
Biological source	Dengue virus 2
Cellular location	Envelope protein E: Virion membrane; Multi- pass membrane protein: Q9WLZ8
Total number of polymer chains	1
Total formula weight	36739.75
Authors	Egloff, M.P.,Marseilles Structural Genomics Program @ AFMB (MSGP) (deposition date: 2007-03-11, release date: 2007-08-28, Last modification date: 2023-08-30)
Primary citation	Egloff, M.P.,Decroly, E.,Malet, H.,Selisko, B.,Benarroch, D.,Ferron, F.,Canard, B. Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372:723-736, 2007 Cited by PubMed: 17686489 DOI: 10.1016/j.jmb.2007.07.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.801 Å)

Structure validation