2OW9

Crystal structure analysis of the MMP13 catalytic domain in complex with specific inhibitor

Summary for 2OW9

Entry DOI	10.2210/pdb2ow9/pdb
Descriptor	Collagenase 3, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	complex crystal structure, martix metalloproteinase, mmp13, specific mmp13 inhibitor, s1' mmp13 inhibitor, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	2
Total formula weight	39711.86
Authors	Pavlovsky, A.G. (deposition date: 2007-02-15, release date: 2007-02-27, Last modification date: 2023-08-30)
Primary citation	Johnson, A.R.,Pavlovsky, A.G.,Ortwine, D.F.,Prior, F.,Man, C.F.,Bornemeier, D.A.,Banotai, C.A.,Mueller, W.T.,McConnell, P.,Yan, C.,Baragi, V.,Lesch, C.,Roark, W.H.,Wilson, M.,Datta, K.,Guzman, R.,Han, H.K.,Dyer, R.D. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J.Biol.Chem., 282:27781-27791, 2007 Cited by PubMed: 17623656 DOI: 10.1074/jbc.M703286200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation