2O44

Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide josamycin

Summary for 2O44

• Entry DOI: 10.2210/pdb2o44/pdb
• Related: 2O43 2O45
• Descriptor: 23S rRNA, (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10S,12E,14Z,16R)-4-(ACETYLOXY)-10-HYDROXY-5-METHOXY-9,16-DIMETHYL-2-OXO-7-(2-OXOETHYL)OXACYCLOHEXADECA-12,14-DIEN-6-YL]OXY}-4-(DIMETHYLAMINO)-5-HYDROXY-2-METHYLTETRAHYDRO-2H-PYRAN-3-YL]OXY}-4-HYDROXY-2,4-DIMETHYLTETRAHYDRO-2H-PYRAN-3-YL 3-METHYLBUTANOATE (2 entities in total)
• Functional Keywords: ribosome, macrolides, rna
• Biological source: Deinococcus radiodurans
• Total number of polymer chains: 1
• Total formula weight: 934232.99

Authors

Pyetan, E.,Daram, D.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2006-12-03, release date: 2007-12-04, Last modification date: 2023-08-30)

• Primary citation: Pyetan, E.,Baram, D.,Auerbach-Nevo, T.,Yonath, A.; Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (3.3 Å)