2NXD

Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA

Summary for 2NXD

Entry DOI	10.2210/pdb2nxd/pdb
Related	1KJG 2NXL 2NXM
Descriptor	PROTEASE RETROPEPSIN, Analogue of RT-RH pol protease substrate peptide (3 entities in total)
Functional Keywords	peptide design; molecular dynamics; hiv protease; substrate recognition; calorimetry, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
Biological source	HIV-1 M:B_ARV2/SF2 More
Total number of polymer chains	3
Total formula weight	22670.72
Authors	Prabu-Jeyabalan, M.,Nalivaika, E.,Schiffer, C.A. (deposition date: 2006-11-17, release date: 2007-09-18, Last modification date: 2023-08-30)
Primary citation	Altman, M.D.,Nalivaika, E.A.,Prabu-Jeyabalan, M.,Schiffer, C.A.,Tidor, B. Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease Proteins, 70:678-694, 2007 Cited by PubMed: 17729291 DOI: 10.1002/prot.21514 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation