2NMP

Crystal structure of human Cystathionine gamma lyase

Summary for 2NMP

Entry DOI	10.2210/pdb2nmp/pdb
Descriptor	Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE (3 entities in total)
Functional Keywords	amino-acid biosynthesis, lyase, pyridoxal phopshate, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P32929
Total number of polymer chains	4
Total formula weight	178084.11
Authors	Karlberg, T.,Uppenberg, J.,Arrowsmith, C.,Berglund, H.,Busam, R.D.,Collins, R.,Edwards, A.,Ericsson, U.B.,Flodin, S.,Flores, A.,Graslund, S.,Hallberg, B.M.,Hammarstrom, M.,Hogbom, M.,Johansson, I.,Kotenyova, T.,Magnusdottir, A.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Stenmark, P.,Sundstrom, M.,Thorsell, A.G.,van-den-Berg, S.,Wallden, K.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2006-10-23, release date: 2006-11-07, Last modification date: 2023-10-25)
Primary citation	Sun, Q.,Collins, R.,Huang, S.,Holmberg-Schiavone, L.,Anand, G.S.,Tan, C.-H.,van-den-Berg, S.,Deng, L.-W.,Moore, P.K.,Karlberg, T.,Sivaraman, J. Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S J.Biol.Chem., 284:3076-3085, 2009 Cited by PubMed: 19019829 DOI: 10.1074/jbc.M805459200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation