2LZK

NMR solution structure of an N2-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: Intercalation from the minor groove with ruptured Watson-Crick base pairing

Summary for 2LZK

• Entry DOI: 10.2210/pdb2lzk/pdb
• NMR Information: BMRB: 18762
• Descriptor: DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'), (11S,12S,13S)-11,12,13,14-tetrahydronaphtho[1,2,3,4-pqr]tetraphene-11,12,13-triol (3 entities in total)
• Functional Keywords: 14r (+)-trans-anti-db[a, l]p-n2-dg, dna adduct, dna
• Total number of polymer chains: 2
• Total formula weight: 7062.79

Authors

Tang, Y.,Liu, Z.,Ding, S.,Lin, C.H.,Cai, Y.,Rodriguez, F.A.,Sayer, J.M.,Jerina, D.M.,Amin, S.,Broyde, S.,Geacintov, N.E. (deposition date: 2012-10-04, release date: 2012-11-21, Last modification date: 2023-06-14)

• Primary citation: Tang, Y.,Liu, Z.,Ding, S.,Lin, C.H.,Cai, Y.,Rodriguez, F.A.,Sayer, J.M.,Jerina, D.M.,Amin, S.,Broyde, S.,Geacintov, N.E.; Nuclear Magnetic Resonance Solution Structure of an N(2)-Guanine DNA Adduct Derived from the Potent Tumorigen Dibenzo[a,l]pyrene: Intercalation from the Minor Groove with Ruptured Watson-Crick Base Pairing.; Biochemistry, 51:9751-9762, 2012; PubMed: 23121427; DOI: 10.1021/bi3013577

Experimental method

SOLUTION NMR