2KKF

Solution structure of MLL CXXC domain in complex with palindromic CPG DNA

Summary for 2KKF

• Entry DOI: 10.2210/pdb2kkf/pdb
• Descriptor: Histone-lysine N-methyltransferase HRX, 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', ZINC ION (3 entities in total)
• Functional Keywords: protein-dna complex, cxxc domain, mll, cpg dna, chromosomal rearrangement, dna-binding, metal-binding, nucleus, zinc-finger, dna binding protein-dna complex, alternative splicing, apoptosis, bromodomain, chromatin regulator, isopeptide bond, methyltransferase, phosphoprotein, polymorphism, proto-oncogene, s-adenosyl-l-methionine, transcription, transcription regulation, transferase, ubl conjugation, zinc, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 3
• Total formula weight: 14137.57

Authors

Cierpicki, T.,Riesbeck, J.E.,Grembecka, J.E.,Lukasik, S.M.,Popovic, R.,Omonkowska, M.,Shultis, D.S.,Zeleznik-Le, N.J.,Bushweller, J.H. (deposition date: 2009-06-18, release date: 2009-12-08, Last modification date: 2022-03-16)

• Primary citation: Cierpicki, T.,Risner, L.E.,Grembecka, J.,Lukasik, S.M.,Popovic, R.,Omonkowska, M.,Shultis, D.D.,Zeleznik-Le, N.J.,Bushweller, J.H.; Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.; Nat.Struct.Mol.Biol., 17:62-68, 2010; PubMed: 20010842; DOI: 10.1038/nsmb.1714

Experimental method

SOLUTION NMR