2K2Q

complex structure of the external thioesterase of the Surfactin-synthetase with a carrier domain

Summary for 2K2Q

• Entry DOI: 10.2210/pdb2k2q/pdb
• Related: 2GDX 2ron
• Descriptor: Tyrocidine synthetase 3 (Tyrocidine synthetase III), Surfactin synthetase thioesterase subunit (2 entities in total)
• Functional Keywords: thioesterase, a/b-hydrolase, nrps, non-ribosomal peptide synthetase, type ii thioesterase, antibiotic biosynthesis, ligase, multifunctional enzyme, phosphopantetheine, sporulation, stress response, ligase-hydrolase complex, ligase/hydrolase
• Biological source: Brevibacillus parabrevis; More
• Cellular location: Cytoplasm: Q08788
• Total number of polymer chains: 2
• Total formula weight: 36557.85

Authors

Koglin, A.,Lohr, F.,Bernhard, F.,Rogov, V.V.,Frueh, D.P.,Strieter, E.R.,Mofid, M.R.,Guntert, P.,Wagner, G.,Walsh, C.T.,Marahiel, M.A.,Dotsch, V. (deposition date: 2008-04-10, release date: 2008-12-09, Last modification date: 2018-01-24)

• Primary citation: Koglin, A.,Lohr, F.,Bernhard, F.,Rogov, V.V.,Frueh, D.P.,Strieter, E.R.,Mofid, M.R.,Guntert, P.,Wagner, G.,Walsh, C.T.,Marahiel, M.A.,Dotsch, V.; Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.; Nature, 454:907-911, 2008; PubMed: 18704089; DOI: 10.1038/nature07161

Experimental method

SOLUTION NMR