2JBU

Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.

Summary for 2JBU

Entry DOI	10.2210/pdb2jbu/pdb
Descriptor	INSULIN-DEGRADING ENZYME, CO-PURIFIED PEPTIDE, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
Functional Keywords	metal-binding, metalloprotease, zinc, protease, hydrolase, enzyme assay, insulin degrading enzyme
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	231348.39
Authors	Im, H.,Shen, Y.,Tang, W.J. (deposition date: 2006-12-11, release date: 2007-07-03, Last modification date: 2023-12-13)
Primary citation	Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J. Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282:25453-, 2007 Cited by PubMed: 17613531 DOI: 10.1074/JBC.M701590200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation