2GVJ

Crystal Structure of Human NMPRTase in complex with FK866

Summary for 2GVJ

Entry DOI	10.2210/pdb2gvj/pdb
Related	2GVG
Descriptor	Nicotinamide phosphoribosyltransferase, (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide (3 entities in total)
Functional Keywords	nmprtase, visfatin, pbef, cancer, fk866, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P43490
Total number of polymer chains	2
Total formula weight	112254.25
Authors	Khan, J.A.,Tao, X.,Tong, L. (deposition date: 2006-05-02, release date: 2006-06-20, Last modification date: 2016-11-09)
Primary citation	Khan, J.A.,Tao, X.,Tong, L. Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat.Struct.Mol.Biol., 13:582-588, 2006 Cited by PubMed: 16783377 DOI: 10.1038/nsmb1105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation