2GQ2

Mycobacterium tuberculosis ThyX-NADP complex

Summary for 2GQ2

• Entry DOI: 10.2210/pdb2gq2/pdb
• Related: 2AF6
• Descriptor: Thymidylate synthase thyX, IODIDE ION, POTASSIUM ION, ... (7 entities in total)
• Functional Keywords: m.tuberculosis, thyx, fdts, tscp, flavin dependent thymidylate synthase, inhibitor design, bivalent drugs, transferase
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 4
• Total formula weight: 121708.31

Authors

Sampathkumar, P.,Turley, S.,Sibley, C.H.,Hol, W.G. (deposition date: 2006-04-19, release date: 2006-06-27, Last modification date: 2023-11-15)

• Primary citation: Sampathkumar, P.,Turley, S.,Sibley, C.H.,Hol, W.G.; NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.; J.Mol.Biol., 360:1-6, 2006; PubMed: 16730023; DOI: 10.1016/j.jmb.2006.04.061

Experimental method

X-RAY DIFFRACTION (2.1 Å)