2G92

Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)

Summary for 2G92

• Entry DOI: 10.2210/pdb2g92/pdb
• Descriptor: 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3' (2 entities in total)
• Functional Keywords: 2, 4-difluorotoluyl nucleoside, chemical modification, rna, rna interference, hydrogen bonding
• Total number of polymer chains: 2
• Total formula weight: 7656.71

Authors

Egli, M.,Li, F. (deposition date: 2006-03-04, release date: 2006-04-18, Last modification date: 2024-04-03)

• Primary citation: Xia, J.,Noronha, A.,Toudjarska, I.,Li, F.,Akinc, A.,Braich, R.,Frank-Kamenetsky, M.,Rajeev, K.G.,Egli, M.,Manoharan, M.; Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.; Acs Chem.Biol., 1:176-183, 2006; PubMed: 17163665; DOI: 10.1021/cb600063p

Experimental method

X-RAY DIFFRACTION (1.61 Å)